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19F Espectroscopia de RMN para el análisis de poblaciones de estructura secundaria de ARN

Dagmar Graber1, Holger Moroder, Ronald Micura

  • 1University of Innsbruck, Institute of Organic Chemistry, Innrain 52a, 6020 Innsbruck, Austria.

Journal of the American Chemical Society
|December 5, 2008
PubMed
Resumen

El etiquetado de flúor específico del sitio permite nuevos conocimientos sobre la estructura del ARN. La espectroscopia de RMN con fluor dependiente de la temperatura cuantifica los equilibrios conformacionales del ARN, ayudando al desarrollo de tecnologías terapéuticas de ARN como siRNA.

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