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Updated: Jun 21, 2026
09:34
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
Published on: October 25, 2018
Dividido en: heterogeneidad dentro de los grupos de células madre adultas
Marc H G P Raaijmakers1, David T Scadden
1Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Cell
|December 17, 2008
Resumen
Las células madre hematopoyéticas (HSC) existen en dos estados funcionales con diferentes velocidades de ciclo celular. Estos HSC pueden cambiar entre estados, creando un grupo proliferativo y una reserva quiescente.
Área de la Ciencia:
- Hematología Hematología.
- Biología de las células madre Biología de las células madre
- Regulación del ciclo celular Reglamento del ciclo celular.
Sus antecedentes:
- Las células madre hematopoyéticas (HSC) son cruciales para la formación de sangre y el mantenimiento de la función inmune.
- Comprender el comportamiento de HSC es clave para la medicina regenerativa y el tratamiento de trastornos de la sangre.
- Investigaciones anteriores sugirieron una población homogénea de HSCs, pero la heterogeneidad funcional es cada vez más reconocida.
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