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Daño colateral causado por la diversificación genética de los receptores de antígenos
Grace K Mahowald1, Jason M Baron, Barry P Sleckman
1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cell
|December 17, 2008
Resumen
La desaminasa inducida por activación (AID) crea roturas de ADN en los oncogenes, lo que contribuye a los cánceres linfoides. AID y RAG pueden colaborar en estas rupturas, ofreciendo nuevos conocimientos sobre el desarrollo del cáncer.
Área de la Ciencia:
- Biología molecular La biología molecular.
- Genética del cáncer Genética del cáncer.
- Inmunología Inmunología.
Sus antecedentes:
- Las translocaciones cromosómicas que unen genes de receptores de antígenos y oncogenes son comunes en las neoplasias linfoides malignas.
- La desaminasa inducida por activación (AID) es crucial para la diversificación de los genes de los receptores de antígenos.
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