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Síntesis total y evaluación de la iso-duocarmycin SA y la iso-yatakemycin

Karen S MacMillan1, Trinh Nguyen, Trihn Nguyen

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|January 22, 2009
PubMed
Resumen

Los investigadores sintetizaron nuevos análogos de la duocarmycina, la iso-duocarmycina SA y la iso-yatakemycina, con subunidades de alquilación alteradas. Estos compuestos muestran una potente alquilación del ADN y citotoxicidad, ofreciendo información sobre el diseño de fármacos de productos naturales.

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