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Videos de Conceptos Relacionados

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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Updated: May 11, 2026

Detection of miRNA Targets in High-throughput Using the 3'LIFE Assay
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Published on: May 25, 2015

MicroARN: reconocimiento de objetivos y funciones reguladoras.

David P Bartel1

  • 1Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. dbartel@wi.mit.edu

Cell
|January 27, 2009
PubMed
Resumen

Los microARN (miRNA) son pequeños ARN que regulan la expresión génica al unirse a los ARN mensajeros. Esta revisión detalla cómo los miRNA reconocen objetivos e impactan la expresión génica y la evolución.

Área de la Ciencia:

  • Biología Molecular Biología Molecular
  • Genética La genética.
  • Reglamento genético Reglamento genético.

Sus antecedentes:

  • Los microARN (miRNA) son pequeñas moléculas de ARN endógenas.
  • Juegan un papel crucial en la regulación de los genes en animales y plantas.
  • Los miARN funcionan emparejándose con los ARN mensajeros (ARNm) de los genes codificadores de proteínas.

Objetivo del estudio:

  • Para esbozar la comprensión actual del reconocimiento de dianas de miRNA en animales.
  • Para discutir el impacto de los miRNA en la expresión génica codificadora de proteínas.
  • Explorar la influencia de los miRNA en la evolución de los genes codificadores de proteínas.

Principales métodos:

  • Revisión de la literatura sobre la investigación del miRNA.

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Last Updated: May 11, 2026

Detection of miRNA Targets in High-throughput Using the 3'LIFE Assay
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MicroRNA-based Regulation of Picornavirus Tropism
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MicroRNA-based Regulation of Picornavirus Tropism

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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

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  • Análisis de los mecanismos de reconocimiento de objetivos de miRNA.
  • Discusión de la regulación génica mediada por miRNA.

    • Principales resultados:

    • Los miRNA reconocen objetivos a través del emparejamiento de bases con los mRNA.
    • Esta interacción conduce a la represión posttranscripcional de la expresión génica.
    • Los miRNA tienen un impacto significativo y generalizado en la expresión génica y la evolución.

    Conclusiones:

    • Comprender el reconocimiento de dianas de miRNA es clave para comprender la regulación génica.
    • Los miRNA son reguladores fundamentales que influyen tanto en la expresión génica como en las trayectorias evolutivas.
    • Una mayor investigación sobre los mecanismos de miRNA iluminará los procesos biológicos fundamentales.