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Reconocimiento de coenzimas y regulación de genes mediante un riboswitch de mononucleótido de flavinas

Alexander Serganov1, Lili Huang, Dinshaw J Patel

  • 1Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. serganoa@mskcc.org

Nature
|January 27, 2009
PubMed
Resumen

Los riboswitches de mononucleótido de flavina (FMN) regulan la expresión génica bacteriana. Los estudios estructurales revelan un único pliegue de ARN parecido a una mariposa, que ofrece información sobre la unión a FMN y posibles objetivos de fármacos antimicrobianos.

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