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Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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La alfa-ariación enantioselectiva intramolecular tipo Friedel-Crafts de los aldehídos

K C Nicolaou1, Rüdiger Reingruber, David Sarlah

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute,10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|January 29, 2009
PubMed
Resumen

La catálisis Organo-SOMO permite nuevas funcionalizaciones de aldehído. Este estudio introduce una arilación intramolecular tipo Friedel-Crafts para la síntesis de desmetil calaméneno, un potencial terapéutico para el cáncer.

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