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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

Catalizado por níquel [4 + 2] cicloadición de enonas con alquinos

Ichiro Koyama1, Takuya Kurahashi, Seijiro Matsubara

  • 1Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.

Journal of the American Chemical Society
|January 29, 2009
PubMed
Resumen

Una nueva reacción catalizada por níquel permite la síntesis de piranos polisubstituidos a partir de enonas y alquinas. El mecanismo implica la ciclización oxidativa mediada por níquel y la inserción de alquino, formando un intermediario clave del ciclo oxa-níquel.

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