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Observación de la agregación de hojas beta en un dímero de péptido tau en fase gaseosa

Timothy D Vaden1, Sally A N Gowers, Lavina C Snoek

  • 1Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK. timothy.vaden@chem.ox.ac.uk

Journal of the American Chemical Society
|January 31, 2009
PubMed
Resumen

En la enfermedad de Alzheimer, los fragmentos de proteína tau se agregan en hojas beta. Estas estructuras se forman fácilmente en la fase gaseosa, impulsadas por enlaces de hidrógeno de la columna vertebral, sin necesidad de influencia de disolventes o proteínas.

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