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Videos de Conceptos Relacionados

The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Excitation-Contraction Coupling in Skeletal Muscles01:20

Excitation-Contraction Coupling in Skeletal Muscles

Excitation-contraction coupling is a series of events that occur between generating an action potential and initiating a muscle contraction. It occurs at the triad, a structure found in skeletal muscle fibers that comprise a T-tubule and terminal cisternae of the sarcoplasmic reticulum on each side. These triads are visible in longitudinally sectioned muscle fibers. They are typically located at the A-I junction — the junction between the A and I bands of the sarcomere.
When an action potential...
Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular cargos...
Actin and Myosin in Muscle Contraction01:16

Actin and Myosin in Muscle Contraction

Actin and myosin are contractile proteins that form the sarcomere found in skeletal muscle tissues for regulating muscle contraction. Actin, a globular contractile protein, interacts with myosin for muscle contraction. The skeletal tissue appears striped or striated under a microscope due to the repeated arrangement of contractile proteins actin and myosin along the length of myofibrils. Dark A bands and light I bands repeat along myofibrils, and the alignment of myofibrils in the cell causes...

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Structural basis for recognition of diverse localizing mRNAs by Egl-BicD.

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Activation and regulation of the dynein-dynactin-NuMA complex.

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Video Experimental Relacionado

Updated: Jun 25, 2026

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers
10:45

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers

Published on: June 3, 2019

Dynein se pone en acción.

Anne Houdusse1, Andrew P Carter

  • 1Structural Motility Team, Institut Curie, Centre de Recherche, Paris, France.

Cell
|February 11, 2009
PubMed
Resumen

Las proteínas motoras de Dynein convierten la energía química en fuerza mecánica para el movimiento. Este estudio revela la disposición estructural de la dineína.

Área de la Ciencia:

  • Biología molecular La biología molecular.
  • Mecánica celular La mecánica celular es la mecánica celular.
  • La bioquímica es la bioquímica.

Sus antecedentes:

  • Las proteínas motoras son máquinas moleculares esenciales que convierten la energía química en trabajo mecánico.
  • La dineína es una proteína motora crucial involucrada en el transporte intracelular y la motilidad.
  • Comprender el mecanismo de generación de fuerza en las proteínas motoras es fundamental para la biología celular.

Objetivo del estudio:

  • Para dilucidar la disposición estructural de los subdominios dentro del dominio motor de la dineína.
  • Proponer un modelo funcional para la generación de fuerza mediada por dynein.

Principales métodos:

  • Análisis estructural del dominio motor de la dineína.
  • Ensayos bioquímicos para estudiar la hidrólisis de ATP y la producción de fuerza.

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Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction
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Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction

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Videos de Experimentos Relacionados

Last Updated: Jun 25, 2026

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers
10:45

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers

Published on: June 3, 2019

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction
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Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction

Published on: April 27, 2011

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo
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Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo

Published on: July 9, 2019

Principales resultados:

  • Descripción detallada del arreglo específico de los subdominios en el dominio motor de la dineína.
  • Un modelo propuesto que ilustra la función coordinada de estos subdominios en la generación de fuerza.

Conclusiones:

  • La disposición específica de los subdominios es crítica para la función motora de la dineína.
  • El modelo propuesto proporciona información sobre el mecanismo molecular de generación de fuerza por dynein.