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Videos de Conceptos Relacionados

Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
Inhibitors Of Virion Release01:25

Inhibitors Of Virion Release

Viral replication and dissemination rely on efficient mechanisms for host cell entry, genome replication, assembly, and release. Influenza viruses, such as types A and B, are negative-sense single-stranded RNA viruses with a segmented genome, that depend on two critical surface glycoproteins to carry out these processes: hemagglutinin (HA) and neuraminidase (NA). HA initiates infection by binding to sialic acid residues on the surface of host epithelial cells, facilitating receptor-mediated...
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...

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Video Experimental Relacionado

Updated: Jun 25, 2026

Influenza Virus Propagation in Embryonated Chicken Eggs
06:56

Influenza Virus Propagation in Embryonated Chicken Eggs

Published on: March 19, 2015

El enigma del virus de la gripe es un enigma.

Rachelle Salomon1, Robert G Webster

  • 1Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN 38105-2678, USA.

Cell
|February 11, 2009
PubMed
Resumen

Los virus de la gripe resistentes a los medicamentos como el H1N1 y el H5N1 representan amenazas significativas para la salud mundial. Una mejor predicción de la gripe estacional y pandémica es crucial para las estrategias efectivas de control.

Área de la Ciencia:

  • Virología Virología.
  • Epidemiología La epidemiología.
  • Salud Pública La salud pública.

Sus antecedentes:

  • Los virus de la gripe estacional y pandémica presentan desafíos continuos para la atención médica.
  • Los virus de la gripe H1N1 resistentes a los medicamentos fueron prevalentes en la temporada 2009.
  • El virus de la gripe aviar H5N1 causa mortalidad en humanos y aves de corral en Eurasia.

Objetivo del estudio:

  • Para discutir la patogénesis y la transmisibilidad de los virus de la gripe.
  • Para resaltar la necesidad de una mejor predicción de los brotes de gripe.

Principales métodos:

  • Revisión de la literatura sobre la patogénesis del virus de la gripe.
  • Análisis de los datos de transmisibilidad de las cepas de influenza.

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In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation
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In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation

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Purification and Visualization of Influenza A Viral Ribonucleoprotein Complexes
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Purification and Visualization of Influenza A Viral Ribonucleoprotein Complexes

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Last Updated: Jun 25, 2026

Influenza Virus Propagation in Embryonated Chicken Eggs
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Influenza Virus Propagation in Embryonated Chicken Eggs

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In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation
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In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation

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Purification and Visualization of Influenza A Viral Ribonucleoprotein Complexes
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Purification and Visualization of Influenza A Viral Ribonucleoprotein Complexes

Published on: February 9, 2009

  • Revisión de los modelos de predicción actuales para la influenza.

    • Principales resultados:

    • La patogénesis del virus de la gripe y la dinámica de transmisión son complejas.
    • Los métodos de predicción existentes para los brotes de gripe requieren mejoras.
    • La resistencia a los medicamentos y la evolución de las cepas virales son las principales preocupaciones.

    Conclusiones:

    • Comprender la patogénesis de la gripe y la transmisibilidad es vital.
    • Es esencial desarrollar predictores superiores para la gripe estacional y pandémica.
    • Se necesita una investigación continua para combatir la evolución de las amenazas de la influenza.