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Updated: Jun 24, 2026

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

Oligómeros 2,2-disubstituido-indolina-3-uno ligados al alquina como imitadores extendidos de la hebra beta

Pauline N Wyrembak1, Andrew D Hamilton

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.

Journal of the American Chemical Society
|March 17, 2009
PubMed
Resumen

Los investigadores diseñaron un nuevo foldamer que imita las hojas beta utilizando unidades de indolinona. Este mimético no peptídico estabiliza una conformación de cadena beta, ofreciendo potencial para nuevas terapias dirigidas a las interacciones proteína-proteína.

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