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La aspirina, los salicilados y el cáncer
Peter C Elwood1, Alison M Gallagher, Garry G Duthie
1School of Medicine, Cardiff University, Cardiff, UK.
Lancet (London, England)
|March 31, 2009
Resumen
La aspirina y los antiinflamatorios no esteroideos pueden reducir el riesgo de cáncer de colon grueso. Se necesita más investigación para confirmar estos hallazgos y explorar mecanismos para la prevención del cáncer.
Área de la Ciencia:
- Oncología Oncología.
- Farmacología Farmacología.
- Gastroenterología y Gastroenterología.
Sus antecedentes:
- Los estudios de observación y la investigación en animales sugieren que la aspirina y los AINE pueden reducir el riesgo de cáncer de colon.
- Las preocupaciones éticas impiden ensayos aleatorizados a gran escala para la prevención del cáncer en humanos.
Objetivo del estudio:
- Resumir la evidencia existente sobre la aspirina y los salicilatos naturales para la prevención del cáncer.
- Discutir posibles mecanismos y futuras direcciones de investigación.
Principales métodos:
- Revisión de la evidencia de varias fuentes, incluidos los ensayos oportunistas.
- Análisis de estudios en animales y datos de observación en humanos.
Principales resultados:
- La evidencia consistente sugiere un riesgo reducido de cáncer de intestino grueso con aspirina y AINE relacionados.
- Los ensayos oportunistas indican una reducción del riesgo de cáncer después de al menos 10 años de uso de aspirina.
Conclusiones:
- La aspirina y los salicilatos naturales muestran potencial para la prevención del cáncer, particularmente para el cáncer de intestino grueso.
- Se justifica una mayor investigación sobre los mecanismos y las implicaciones clínicas.
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