Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

DNA Packaging00:58

DNA Packaging

Overview
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
DNA Packaging00:58

DNA Packaging

Overview
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Chromatin architecture sets origin licensing capacity.

Research square·2026
Same author

Chromatin architecture sets origin licensing capacity.

bioRxiv : the preprint server for biology·2026
Same author

CAD-C reveals centromere pairing and near-perfect alignment of sister chromatids.

bioRxiv : the preprint server for biology·2026
Same author

Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals.

bioRxiv : the preprint server for biology·2025
Same author

Chromatin architecture mapping by multiplex proximity tagging.

Molecular cell·2025
Same author

ChIP-seq Data Processing and Relative and Quantitative Signal Normalization for <i>Saccharomyces cerevisiae</i>.

Bio-protocol·2025

Video Experimental Relacionado

Updated: May 12, 2026

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
07:37

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion

Published on: June 25, 2017

Abrir ventanas hacia el genoma.

Iestyn Whitehouse1, Toshio Tsukiyama

  • 1Sloan-Kettering Institute, New York, NY 12750, USA. whitehoi@mskcc.org

Cell
|May 5, 2009
PubMed
Resumen

Los reguladores de la cromatina pueden cambiar la posición de los nucleosomas en los promotores de genes. Este estudio muestra cómo el posicionamiento de los nucleosomas afecta la regulación génica en la levadura.

Área de la Ciencia:

  • Biología Molecular Biología Molecular
  • Genética La genética.
  • La epigenética es la epigenética.

Sus antecedentes:

  • El posicionamiento de los nucleosomas es crucial para controlar la expresión génica.
  • Comprender cómo la estructura de la cromatina influye en la transcripción es un área activa de investigación.

Objetivo del estudio:

  • Para investigar el papel de los reguladores de la cromatina en el posicionamiento de los nucleosomas.
  • Para demostrar el impacto de la posición alterada de los nucleosomas en la regulación transcripcional en Saccharomyces cerevisiae.

Principales métodos:

  • Mapeo del posicionamiento de los nucleosomas a través del genoma.
  • Analizando los efectos de un regulador específico de la cromatina en los promotores de genes.

Más Videos Relacionados

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos
10:35

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

Published on: October 3, 2018

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
10:16

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

Videos de Experimentos Relacionados

Last Updated: May 12, 2026

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
07:37

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion

Published on: June 25, 2017

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos
10:35

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

Published on: October 3, 2018

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
10:16

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

Principales resultados:

  • Se descubrió que un regulador de la cromatina altera el posicionamiento de los nucleosomas en los promotores de numerosos genes.
  • Esta alteración en el posicionamiento de los nucleosomas tiene implicaciones significativas para la regulación génica.

Conclusiones:

  • El posicionamiento del nucleosoma es un mecanismo clave regulado por los modificadores de la cromatina.
  • Este estudio pone de relieve el poder del mapeo de nucleosomas en la comprensión del control transcripcional.