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Updated: Jun 23, 2026

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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La inhibición de la actividad de la gamma-secretasa por los foldameres helical de péptido beta

Yuki Imamura1, Naoto Watanabe, Naoki Umezawa

  • 1Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603.

Journal of the American Chemical Society
|May 13, 2009
PubMed
Resumen

Los nuevos foldamers de beta-péptido que adoptan una estructura helicoidal inhiben efectivamente la gamma-secretasa, un objetivo clave para el tratamiento de la enfermedad de Alzheimer (EA). Este descubrimiento ofrece una ventaja prometedora para el desarrollo de nuevas terapias AD y herramientas de investigación.

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