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Elucidación del mecanismo de transporte de protones en la anhidrase carbónica humana II

C Mark Maupin1, Robert McKenna, David N Silverman

  • 1Center for Biophysical Modeling and Simulation and Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.

Journal of the American Chemical Society
|May 15, 2009
PubMed
Resumen

La anhidrase carbónica humana II utiliza un grupo de agua para el transporte de protones, crucial para su rápida actividad enzimática. La orientación de His64 y la estabilidad del grupo de agua impactan significativamente en este paso limitador de velocidad.

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