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La liberación de óxido nítrico fotoinducida de un derivado de nitrobenzeno obstaculizado por excitación de dos

Kazuhiro Hishikawa¹, Hidehiko Nakagawa, Toshiaki Furuta

¹Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

Journal of the American Chemical Society

|May 15, 2009

Resumen

Este estudio muestra una nueva forma de generar óxido nítrico (NO) utilizando un compuesto especial y luz láser de excitación de dos fotones (TPE). Este método ofrece un control preciso de la liberación de NO para aplicaciones potenciales.

Área de la Ciencia:

La fotoquímica es la fotoquímica.
Química del óxido nítrico Química del óxido nítrico
Síntesis orgánica La síntesis orgánica.

Sus antecedentes:

El óxido nítrico (NO) es una molécula de señalización crucial en los sistemas biológicos.
El desarrollo de compuestos controlados de liberación de NO es importante para la investigación y la terapéutica.
Los donantes de NO existentes a menudo dependen de quelantes específicos o métodos de excitación más simples.

Objetivo del estudio:

Para demostrar la generación de óxido nítrico (NO) fotoinducida a partir de un nuevo compuesto a base de 2,6-dimetilnitrobenzeno (Flu-DNB).
Investigar la viabilidad del uso de la excitación de dos fotones (TPE) para la liberación controlada de NO.
Establecer una nueva clase de donantes de NO activados por TPE.

Principales métodos:

Síntesis del compuesto basado en 2,6-dimetilnitrobenzeno (Flu-DNB).
Irradiación de las soluciones Flu-DNB utilizando láser pulsado para la excitación de dos fotones (TPE).
Detección y análisis de los productos de oxidación del óxido nítrico (NO).

Principales resultados:

Se confirmó el éxito de la generación fotoinducida de NO de Flu-DNB.
La generación de NO fue controlada efectivamente por el proceso de TPE.
Se observaron productos de oxidación de NO después de la irradiación láser, validando la liberación de NO.

Conclusiones:

Flu-DNB sirve como un donante efectivo de NO activado por la excitación de dos fotones (TPE).
Este trabajo presenta el primer ion metálico no quelado con nitrosilo que contiene donante de NO controlable por TPE.
La generación de NO controlada por TPE ofrece una nueva plataforma para la entrega precisa de NO.

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