Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Blood Flow01:29

Blood Flow

57.4K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
57.4K
Hematopoiesis01:21

Hematopoiesis

8.1K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.1K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

9.8K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
9.8K
Production of Formed Elements01:34

Production of Formed Elements

7.5K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
7.5K
Structure of Blood Vessels01:15

Structure of Blood Vessels

11.8K
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
11.8K
Development of Blood Vessels01:07

Development of Blood Vessels

2.0K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
2.0K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

A progeria syndrome links DNA hypermethylation to age-related pathology.

Nature genetics·2026
Same author

How changes in salinity modify patterns of gastrointestinal motility in the intestine of freshwater barramundi.

Autonomic neuroscience : basic & clinical·2026
Same author

Assessing the Tautomerase Activity of MIF Using L-Dopachrome.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Using Luciferase Reporter Cells to Assess the Effects of MIF Inhibitors on NF-κB Activation.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Age, sex, smoking-specific prevalence and progression in interstitial lung abnormality: patient-level meta-analysis.

Annals of the American Thoracic Society·2026
Same author

Engineering Antimicrobial Peptides via Motif Assembly for Combating Multidrug-Resistant Pathogens.

Journal of medicinal chemistry·2026

Video Experimental Relacionado

Updated: May 3, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

15.6K

El desarrollo de las células madre hematopoyéticas depende del flujo sanguíneo.

Trista E North1, Wolfram Goessling, Marian Peeters

  • 1Stem Cell Program and Hematology/Oncology, Children's Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.

Cell
|May 20, 2009
PubMed
Resumen

El flujo sanguíneo es un regulador conservado de la formación de células madre hematopoyéticas (HSC) durante la embriogénesis de vertebrados. El óxido nítrico (NO) actúa como un mediador aguas abajo, crucial para el desarrollo de HSC en la región aorta-gonadas-mesonefros.

Más Videos Relacionados

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

5.5K
Author Spotlight: Studying hiPSC-Derived Endothelial Cells Cultured Under Fluidic-Mediated Mechanical Stimulation
09:12

Author Spotlight: Studying hiPSC-Derived Endothelial Cells Cultured Under Fluidic-Mediated Mechanical Stimulation

Published on: July 28, 2023

2.1K

Videos de Experimentos Relacionados

Last Updated: May 3, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

15.6K
Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

5.5K
Author Spotlight: Studying hiPSC-Derived Endothelial Cells Cultured Under Fluidic-Mediated Mechanical Stimulation
09:12

Author Spotlight: Studying hiPSC-Derived Endothelial Cells Cultured Under Fluidic-Mediated Mechanical Stimulation

Published on: July 28, 2023

2.1K

Área de la Ciencia:

  • Biología del desarrollo Biología del desarrollo.
  • La hematopoyesis es la hematopoyesis.
  • Biología Vascular Biología Vascular

Sus antecedentes:

  • Las células madre hematopoyéticas (HSC) son esenciales para la formación de sangre y se originan en la región aorta-gonadas-mesonefros (AGM) durante la embriogénesis de los vertebrados.
  • Los mecanismos reguladores precisos que rigen la aparición de HSC en la AGM siguen siendo un área activa de investigación.

Objetivo del estudio:

  • Para investigar el papel del flujo sanguíneo como un regulador conservado de la formación de HSC.
  • Identificar vías de señalización aguas abajo involucradas en el desarrollo de HSC mediado por flujo.

Principales métodos:

  • Se utilizaron modelos de pez cebra con moduladores químicos del flujo sanguíneo y mutaciones genéticas que afectan la circulación (mutantes del corazón silencioso).
  • Se administraron donantes de óxido nítrico (NO) y se empleó morfolino para eliminar el NO1 (nnos/enos) en el pez cebra.
  • Modelos de ratón examinados con inhibición intrauterina de NO y deficiencia embrionaria de Nos3.

Principales resultados:

  • Los embriones de pez cebra con flujo sanguíneo deteriorado exhibieron HSC significativamente reducidos.
  • Los donantes NO rescataron el desarrollo de HSC en peces cebra con problemas de flujo, incluso cuando se administraron antes del inicio de la circulación.
  • La reducción del número 1 en el pez cebra fue celular-autónoma, y la deficiencia del número 3 en ratones redujo los grupos hematopoyéticos y los HSCs transplantables.

Conclusiones:

  • El flujo sanguíneo es un regulador conservado del desarrollo de HSC en la región AGM.
  • El óxido nítrico (NO) es un mediador clave aguas abajo en la regulación dependiente del flujo sanguíneo de la formación de HSC.
  • Este estudio establece un vínculo directo entre la dinámica vascular y las primeras etapas de la hematopoyesis.