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Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
Imaging Studies VI: Voiding Cystourethrography and Cystography01:22

Imaging Studies VI: Voiding Cystourethrography and Cystography

Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
Nursing Assessment of the Genitourinary System II: Inspection and Palpation01:26

Nursing Assessment of the Genitourinary System II: Inspection and Palpation

The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...

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Updated: Jun 22, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

El cáncer de vejiga es un cáncer de vejiga.

Donald S Kaufman1, William U Shipley, Adam S Feldman

  • 1Department of Medicine, the Claire and John Bertucci Center for Genitourinary Cancers, Massachusetts General Hospital, Boston, MA 02114, USA. dskaufman@partners.org

Lancet (London, England)
|June 13, 2009
PubMed
Resumen
Este resumen es generado por máquina.

El cáncer de vejiga varía desde tumores superficiales que no ponen en peligro la vida hasta enfermedades invasivas musculares mortales. El tratamiento abarca desde terapia intravesical y cirugía hasta estrategias de preservación de la vejiga y quimioterapia.

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Área de la Ciencia:

  • Urología Urología Urología.
  • Oncología Oncología.

Sus antecedentes:

  • El cáncer de vejiga es una enfermedad heterogénea con comportamientos clínicos distintos.
  • Los tumores superficiales se repiten pero son menos peligrosos para la vida, mientras que las enfermedades invasivas musculares conllevan un alto riesgo de mortalidad.
  • La hematuria indolora es el síntoma principal, diagnosticado a través de citología y resección transuretral.

Objetivo del estudio:

  • Para revisar la comprensión actual y el tratamiento del cáncer de vejiga.
  • Para discutir los métodos de diagnóstico y las opciones terapéuticas para las diferentes etapas del cáncer de vejiga.
  • Explorar tratamientos emergentes, incluida la preservación de la vejiga, la quimioterapia, las terapias dirigidas y los avances moleculares.

Principales métodos:

  • Revisión de la literatura actual sobre el diagnóstico y tratamiento del cáncer de vejiga.
  • Discusión de la atención estándar para el cáncer de vejiga superficial e invasivo muscular.
  • Exploración de técnicas de preservación de la vejiga y terapias sistémicas.

Principales resultados:

  • Los tratamientos intravesicos son efectivos para el carcinoma in situ y los tumores no invasivos musculares de alto grado.
  • La cistostatectomía radical con desviación urinaria es estándar para enfermedades invasivas musculares.
  • La preservación de la vejiga y varios agentes quimioterapéuticos son prometedores.

Conclusiones:

  • El manejo del cáncer de vejiga requiere enfoques personalizados basados en la etapa de la enfermedad.
  • Los avances en quimioterapia, terapia dirigida y biología molecular están mejorando las opciones de tratamiento.
  • La calidad de vida es una consideración crítica en la desviación urinaria y la planificación del tratamiento.