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Updated: Mar 30, 2026

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
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El ensamblaje impulsado por la fosforilación del complejo RIP1-RIP3 regula la necrosis programada y la inflamación

Young Sik Cho1, Sreerupa Challa, David Moquin

  • 1Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Cell
|June 16, 2009
PubMed
Resumen

La quinasa RIP3 es esencial para la necrosis programada, una vía de muerte celular. RIP3 activa la fosforilación de RIP1, iniciando una cascada crucial para las respuestas inflamatorias durante las infecciones virales.

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