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Bases estructurales de la inhibición del cianuro de la deshidrogenasa de monóxido de carbono que contiene Ni, Fe

Jae-Hun Jeoung1, Holger Dobbek

  • 1Labor für Bioanorganische Chemie, Universität Bayreuth, 95447 Bayreuth, Germany.

Journal of the American Chemical Society
|July 9, 2009
PubMed
Resumen

El cianuro inhibe las deshidrogenasas de monóxido de carbono (CODH) al unirse al ion níquel en el grupo C. Esta unión obstruye el acceso al sustrato y causa cambios conformacionales, lo que explica sus efectos inhibidores.

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