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Detection of DNA Breaks in Dividing Human Cells by Neutral Comet Assay
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Hannah L Klein1, Lorraine S Symington
1Department of Biochemistry, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, USA. hannah.klein@nyumc.org
Cell
|July 15, 2009
Resumen
La proteína SLX4 humana actúa como un andamio para las enzimas. Funciona con la endonucleasa SLX1 para resolver estructuras complejas de ADN llamadas uniones de Holliday.
Área de la Ciencia:
- Biología molecular La biología molecular.
- Genética La genética.
- Reparación del ADN, reparación del ADN.
Sus antecedentes:
- Se sabe que la proteína SLX4 armazona subunidades catalíticas de endonucleasas específicas de la estructura.
- Estudios previos han implicado a SLX4 en varias vías de reparación del ADN.
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