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Bcl6 interviene en el desarrollo de las células auxiliares foliculares T

Roza I Nurieva¹, Yeonseok Chung, Gustavo J Martinez

¹Department of Immunology, M. D. Anderson Cancer Center, Houston, TX 77030, USA. rnurieva@mdanderson.org

Science (New York, N.Y.)

|July 25, 2009

Resumen

El factor de transcripción Bcl6 es esencial para la generación de células T foliculares auxiliares (T(FH), que regulan la inmunidad de las células B. Su expresión adecuada, influenciada por citocinas específicas, es crítica para el desarrollo y la función de las células T (((FH).

Área de la Ciencia:

Inmunología Inmunología.
Biología Molecular Biología Molecular
Biología celular Biología celular.

Sus antecedentes:

Las células T (T(H)) ayudantes CD4+ regulan la inmunidad humoral de las células B.
El desarrollo de células T foliculares auxiliares (TFH) es dependiente de las citoquinas (IL-6, IL-21) y es distinto de otros linajes TH.
El factor de transcripción Bcl6 se expresa selectivamente en las células T (FH).

Objetivo del estudio:

Caracterizar la función del factor de transcripción Bcl6 en el desarrollo y la diferenciación celular de las células T (((FH).
Investigar los mecanismos reguladores que controlan la expresión de Bcl6 y su papel en la programación de la línea celular T (H).

Principales métodos:

Análisis de la expresión de Bcl6 en las células T (((FH).
Estudios de sobreexpresión de Bcl6 para evaluar su impacto en la expresión génica y la diferenciación celular.
Estudios de deficiencia genética (Bcl6 knockout) para evaluar su papel en el desarrollo celular de T (FH) y las reacciones del centro germinal.

Principales resultados:

La expresión de Bcl6 está regulada por la interleucina-6 e interleucina-21.
La sobreexpresión de Bcl6 induce la expresión génica relacionada con T(FH) e inhibe otra diferenciación del linaje T(H) de una manera dependiente de la unión al ADN.
La deficiencia de Bcl6 afecta el desarrollo de las células T ((FH), las reacciones del centro germinal y altera la producción de subconjuntos de células T efectoras.

Conclusiones:

Bcl6 es un factor de transcripción clave requerido para la programación y generación de células T (FH).
Bcl6 juega un papel crítico en la orquestación de la diferenciación y función de las células T ((FH) dentro del sistema inmunológico.

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