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Muerte celular: un nuevo Par-4 el TRAIL.
Lori S Hart1, Wafik S El-Deiry
1Laboratory of Molecular Oncology and Cell Cycle Regulation, Department of Medicine (Hematology/Oncology), University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
Cell
|July 28, 2009
Resumen
La proteína Par-4, que normalmente actúa dentro de las células para desencadenar la apoptosis, también puede promover la muerte celular programada desde fuera de la célula. Esta secreción se produce después del estrés del retículo endoplasmático, revelando un nuevo papel extracelular para Par-4 en la señalización de la muerte celular.
Área de la Ciencia:
- Biología celular Biología celular.
- Biología molecular La biología molecular.
- La bioquímica es la bioquímica.
Sus antecedentes:
- Se sabe que la proteína Par-4 funciona en el citoplasma.
- La par-4 inicia la señalización de la muerte celular a través de la activación de la caspasa.
- También media la liberación mitocondrial del citocromo c.
Objetivo del estudio:
- Para investigar las posibles funciones extracelulares de Par-4.
- Para explorar el papel de Par-4 en la apoptosis después de la secreción.
Principales métodos:
- Se investigó la secreción Par-4.
- Analizó el efecto de Par-4 en la apoptosis después de la secreción.
- Estudió el papel del estrés del retículo endoplasmático en la secreción de Par-4.
Principales resultados:
- Par-4 se secreta en respuesta al estrés en el retículo endoplasmático.
- El Par-4 extracelular puede promover la apoptosis.
- Esto sugiere un nuevo mecanismo para la regulación de la muerte celular.
Conclusiones:
- Par-4 tiene un doble papel en la apoptosis, actuando tanto intracelular como extracelular.
- El estrés en el retículo endoplasmático puede desencadenar la secreción de Par-4.
- Extracelular Par-4 representa un nuevo objetivo para la modulación de la muerte celular.
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