Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Antibody Structure01:10

Antibody Structure

51.8K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
51.8K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

10.9K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
10.9K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

2.1K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.1K
Development of Immunocompetence01:22

Development of Immunocompetence

1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Pyruvylation of STAT1 inhibits anti-viral immunity: Prospects for new anti-viral therapeutics.

Molecular cell·2026
Same author

4-Octyl itaconate blocks STAT3-induced ACE2 expression to reduce uptake of SARS-CoV-2.

Biochemical pharmacology·2026
Same author

Retraction Note: MAVS is a sensor of fumarate during antiviral immunity.

Nature microbiology·2026
Same author

Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages.

Cellular & molecular immunology·2026
Same author

Mitochondria target the plasma membrane to cause mitoxyperiosis.

Cell research·2026
Same author

Mitochondrial glutathione transporter SLC25A40 regulates macrophage cytokine production.

Scientific reports·2025

Video Experimental Relacionado

Updated: May 3, 2026

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
10:22

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

Published on: November 12, 2015

8.2K

El ADN hace ARN hace inmunidad innata.

Luke A J O'Neill1

  • 1School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland. laoneill@tcd.ie

Cell
|August 12, 2009
PubMed
Resumen

El ADN citosólico desencadena la inmunidad innata y la producción de interferón beta (IFN-beta). Los investigadores identificaron la ARN polimerasa III dependiente del ADN como el sensor clave que vincula el ADN microbiano en el citosol de la célula huésped con esta respuesta inmune.

Área de la Ciencia:

  • Inmunología Inmunología.
  • Biología Molecular Biología Molecular
  • Microbiología Microbiología.

Sus antecedentes:

  • El ADN microbiano en el citosol de la célula huésped activa las respuestas inmunes innatas.
  • El interferón-beta (IFN-beta) es una citocina clave en la inmunidad antiviral y antibacteriana.

Objetivo del estudio:

  • Para identificar el sensor de ADN citosólico responsable de iniciar la respuesta inmune innata.
  • Para aclarar el mecanismo que vincula la detección de ADN microbiano a la producción de IFN-beta.

Principales métodos:

  • El estudio probablemente involucró ensayos basados en células para detectar la producción de IFN-beta tras la estimulación con ADN microbiano.
  • Técnicas como la interferencia de ARN o los knockouts genéticos pueden haber sido utilizados para identificar el sensor de ADN.

Más Videos Relacionados

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
08:14

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

Published on: October 26, 2018

8.0K
In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
12:23

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

Published on: September 7, 2022

1.7K

Videos de Experimentos Relacionados

Last Updated: May 3, 2026

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
10:22

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

Published on: November 12, 2015

8.2K
Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
08:14

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

Published on: October 26, 2018

8.0K
In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
12:23

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

Published on: September 7, 2022

1.7K
  • Se podría haber empleado Western blotting o ELISA para medir los niveles de IFN-beta.

    • Principales resultados:

    • El ADN citosólico desencadena la producción de interferón-beta (IFN-beta).
    • La ARN polimerasa III, dependiente del ADN, fue identificada como el sensor del ADN microbiano citosólico.
    • Este sensor vincula la presencia de ADN bacteriano y viral patógeno en el citosol con la producción de IFN-beta y la inmunidad innata.

    Conclusiones:

    • La ARN polimerasa III dependiente del ADN actúa como un sensor crucial para el ADN citosólico.
    • Este mecanismo de detección es vital para iniciar la respuesta inmune innata contra las infecciones microbianas.
    • Los hallazgos proporcionan una base molecular para cómo la célula huésped detecta el ADN microbiano intracelular y activa las vías de señalización inmune.