Search research articles

ACERCA DE JoVE

Visión General Liderazgo Blog Centro de Ayuda JoVE

AUTORES

Proceso de Publicación Consejo Editorial Alcance y Políticas Revisión por Pares Preguntas Frecuentes Enviar

BIBLIOTECARIOS

Testimonios Suscripciones Acceso Recursos Consejo Asesor de Bibliotecas Preguntas Frecuentes

INVESTIGACIÓN

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archivo

EDUCACIÓN

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Centro de Recursos para Profesores Sitio de Profesores

Términos y Condiciones de Uso

Política de Privacidad

Videos de Conceptos Relacionados

Cholecystitis

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Gallbladder

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

Gastritis II: Pathophysiology

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...

Gastritis-I: Introduction and Types

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por

Same author

Club Rhumatismes et Inflammation guidelines for anti-interleukin-1 therapy: 2026 update.

Joint bone spine·2026

Same author

Reliability of ultrasound assessment of elementary lesions in psoriatic arthritis and development of a reference dactylitis atlas.

Rheumatology (Oxford, England)·2026

Same author

Urate Lowering and Cardiovascular Risk-Extending the Benefits of a Treat-to-Target Strategy in Gout.

JAMA internal medicine·2026

Same author

Screening for transthyretin amyloid cardiomyopathy in patients with musculoskeletal symptoms: Red flags in the rheumatology/orthopedics practice setting.

Joint bone spine·2025

Same author

Transcutaneous auricular vagus nerve stimulation versus sham stimulation in patients with erosive hand osteoarthritis (ESTIVAL): a randomised, multicentre, double-blind, sham-controlled trial.

The Lancet. Rheumatology·2025

Same author

Photon-counting CT of Bone Erosions Induced by Gouty Tophi.

Radiology·2025

Same journal

Convergence of metabolic risk in obesity and normal BMI: does risk disappear?

Lancet (London, England)·2026

Same journal

Metabolic traits in obesity and normal BMI in industrialised countries: a multi-country analysis of national population-based studies.

Lancet (London, England)·2026

Same journal

Safety and efficacy of mRNA vaccines: a mechanistic and public health perspective.

Lancet (London, England)·2026

Same journal

The US Ebola response and the future of global health leadership.

Lancet (London, England)·2026

Same journal

Daniel Mason: a tale of change.

Lancet (London, England)·2026

Same journal

The 2026 Wakley-Wu Lien Teh Prize Essay: why medicine, and why stay?

Lancet (London, England)·2026

Ver todos los artículos relacionados

Search research articles

Video Experimental Relacionado

Updated: Jun 20, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

La gota es la gota.

Pascal Richette¹, Thomas Bardin

¹Université Paris 7, UFR Médicale, Assistance Publique-Hôpitaux de Paris, Hôpital Lariboisière, Fédération de Rhumatologie, Paris, France. pascal.richette@lrb

Lancet (London, England)

|August 21, 2009

Resumen

Este resumen es generado por máquina.

La gota, una artritis inflamatoria común causada por la acumulación de cristales de ácido úrico, afecta al 1-2% de los adultos. La reducción del ácido úrico sérico disuelve los cristales, cura la gota, junto con los cambios en el estilo de vida y el manejo de la comorbilidad.

Videos de Experimentos Relacionados

Last Updated: Jun 20, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Área de la Ciencia:

Reumatología Reumatología.
Enfermedades Metabólicas Las enfermedades metabólicas.
Las Artropatías Cristalinas.

Sus antecedentes:

La gota es una artritis inflamatoria prevalente causada por la deposición de cristales de urato monosódico debido a la hiperuricemia crónica.
Afectando al 1-2% de los adultos en los países desarrollados, la gota es la artritis inflamatoria más común en los hombres, con una prevalencia creciente.
La gota primaria está relacionada con la dieta y los factores genéticos que influyen en los transportadores renales de urato.

Objetivo del estudio:

Revisar la epidemiología, las causas, las comorbilidades y el tratamiento de la gota.
Para resaltar los objetivos terapéuticos actuales y potenciales para el manejo de la gota.
Para enfatizar la importancia de la educación del paciente y el tratamiento de la comorbilidad.

Principales métodos:

Revisión de la literatura de datos epidemiológicos sobre la prevalencia de la gota y los factores de riesgo.
Análisis de los tratamientos farmacológicos actuales para los ataques agudos de gota.
Discusión de objetivos terapéuticos emergentes, incluida la Interleucina-1beta.

Principales resultados:

La prevalencia de la gota está aumentando, asociada con el estilo de vida y los factores genéticos.
Los antiinflamatorios no esteroideos y la colchicina son tratamientos estándar para el tratamiento agudo; los corticosteroides orales son una alternativa.
La reducción del ácido úrico sérico por debajo del punto de saturación puede disolver los cristales y curar la gota.

Conclusiones:

El manejo de la gota requiere abordar la hiperuricemia, los ataques agudos y las comorbilidades asociadas.
Las estrategias terapéuticas incluyen la modificación del estilo de vida, la farmacoterapia y potencialmente dirigirse a mediadores inflamatorios como la Interleucina-1beta.
Lograr una reducción sostenida en el ácido úrico sérico es clave para resolver la gota y prevenir la formación de cristales.