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A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.
Published on: November 7, 2018
La fiebre tifoidea en los Estados Unidos, 1999-2006
Michael F Lynch1, Elizabeth M Blanton, Sandra Bulens
1Enteric Diseases Epidemiology Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F-22, Atlanta, GA 30341, USA. mlynch1@cdc.gov
JAMA
|August 27, 2009
Resumen
Las infecciones por Salmonella Typhi resistentes a los antimicrobianos en los Estados Unidos están relacionadas con los viajes, particularmente al subcontinente indio. La resistencia al ácido nalidixico y la disminución de la susceptibilidad a las fluoroquinolonas están aumentando las preocupaciones por la fiebre tifoidea.
Área de la Ciencia:
- Microbiología Microbiología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Vigilancia de la salud pública.
Sus antecedentes:
- La fiebre tifoidea en los EE.UU. es cada vez más causada por Salmonella Typhi resistente a los medicamentos.
- La vigilancia nacional es crucial para guiar las estrategias de prevención y tratamiento.
Objetivo del estudio:
- Para analizar las tendencias en las infecciones por Salmonella Typhi (S. Typhi) resistentes a los antimicrobianos.
Principales métodos:
- Un estudio transversal basado en el laboratorio analizó los datos de 1999-2006.
- Incluidos 1902 casos de fiebre tifoidea y 2016 aislamientos de S. Typhi probados para la susceptibilidad a los antimicrobianos.
- Las proporciones de resistencia examinadas y los factores de riesgo del paciente para las infecciones resistentes.
Principales resultados:
- El S. Typhi multirresistente (MDRST) y el S. Typhi resistente al ácido nalidixico (NARST) se identificaron en el 13% y el 38% de los aislados, respectivamente.
- La proporción de NARST aumentó del 19% al 54% entre 1999 y 2006.
- Los viajes al subcontinente indio estaban fuertemente asociados con las infecciones por MDRST (OR 7.5) y NARST (OR 20.4).
Conclusiones:
- Las infecciones por S. Typhi resistentes a los antimicrobianos en pacientes estadounidenses están asociadas con viajes al subcontinente indio.
- El aumento de las tasas de S. Typhi con una susceptibilidad reducida a las fluoroquinolonas es una preocupación creciente.
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