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Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
Mechanism of Breathing I: Inspiration01:30

Mechanism of Breathing I: Inspiration

Introduction to Inspiration: The Respiratory System in Action
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
Alterations in Respiration II01:30

Alterations in Respiration II

There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes include...
Mechanism of Breathing II: Expiration01:23

Mechanism of Breathing II: Expiration

The Physiology of Expiration: A Seamless Respiratory Process
Expiration, or exhaling, is a complex physiological process that begins as the inspiratory muscles begin to relax. This relaxation triggers a series of events that epitomize the efficiency of the respiratory system.
Mechanism of Expiration:
Assessment of Ventilation II: Respiratory Depth and Rhythm01:29

Assessment of Ventilation II: Respiratory Depth and Rhythm

Respiratory Depth
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:
Respiratory Volumes01:15

Respiratory Volumes

Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...

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Video Experimental Relacionado

Updated: Jun 20, 2026

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways
09:39

A Microfluidic Model of Biomimetically Breathing Pulmonary Acinar Airways

Published on: May 9, 2016

Las vesículas que "respiran"

Shaoyong Yu1, Tony Azzam, Isabelle Rouiller

  • 1Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, H3A 2K6, Canada.

Journal of the American Chemical Society
|September 3, 2009
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio introduce vesículas sensibles al pH con una capacidad única de "respiración", cambiando de tamaño de manera reversible y permitiendo la difusión de especies. Estas vesículas inteligentes ofrecen un rápido transporte de protones y una permeabilidad controlada.

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Área de la Ciencia:

  • Ciencia de los materiales Ciencia de los materiales.
  • Química de Polímeros La Química de Polímeros es la química de los polímeros.
  • Nanotecnología La nanotecnología es la nanotecnología.

Sus antecedentes:

  • Las vesículas son cruciales en la administración de medicamentos y en la nanotecnología.
  • Los materiales sensibles al pH ofrecen un control dinámico sobre las propiedades de las vesículas.
  • La hinchazón y la permeabilidad controladas son claves para aplicaciones avanzadas.

Objetivo del estudio:

  • Para sintetizar y caracterizar un nuevo copolímero triblock para vesículas sensibles al pH.
  • Para investigar los cambios estructurales inducidos por el pH y las transiciones de volumen de estas vesículas.
  • Para evaluar el impacto de los cambios de pH en la permeabilidad de las vesículas y el transporte de iones.

Principales métodos:

  • Síntesis de poli (óxido de etileno) -bloque de poliestireno-bloque de poli (methacrilato de 2-dietilaminoetil) (PEO-b-PS-b-PDEA) a través de ATRP.
  • El autoensamblaje de las vesículas a un pH alto (aprox. 10.4.4) de las mismas.
  • Microscopía electrónica de transmisión criogénica (cryo-TEM) para el análisis estructural.
  • Caracterización dependiente del pH del tamaño de la vesícula, el grosor de la pared y la permeabilidad.

Principales resultados:

  • Las vesículas exhiben una estructura de pared de tres capas (PS-PDEA-PS) con hinchazón dependiente del pH.
  • Un cambio de volumen significativo y reversible (aprox. 7 veces) ocurre con una disminución del pH debido a la protonación e hidratación de PDEA.
  • La disminución del pH conduce a un aumento del tamaño de las vesículas, el grosor de la pared y el agrietamiento de las capas de PS, mejorando la permeabilidad del agua y los protones.
  • Tiempo de relajación rápida (aprox. 1 min) y una alta reversibilidad observada a través de un pH de 10.4 a 3.4.

Conclusiones:

  • El copolímero sintetizado de PEO-b-PS-b-PDEA forma vesículas robustas y sensibles al pH con propiedades sintonizables.
  • El mecanismo de "respiración" permite la difusión controlada de las especies y el transporte rápido de protones.
  • Estas vesículas tienen potencial para aplicaciones que requieren cambios dinámicos de volumen y permeabilidad controlada, como los sistemas inteligentes de administración de medicamentos.