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Updated: Jun 20, 2026

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

Los efectos de la isomerización de la prolina cis-trans en la estabilidad de la triple hélice de colágeno son

Nan Dai1, Felicia A Etzkorn

  • 1Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, USA.

Journal of the American Chemical Society
|September 4, 2009
PubMed
Resumen

La restricción de la isomerización cis-trans de la prolina en los péptidos de colágeno redujo significativamente la estabilidad de la triple hélice. Esto sugiere que la isomerización de prolina individual tiene un impacto mínimo, pero los efectos acumulativos en el colágeno pueden ser sustanciales.

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