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Las redes perineuronales protegen los recuerdos del miedo de ser borrados
Nadine Gogolla1, Pico Caroni, Andreas Lüthi
1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
Science (New York, N.Y.)
|September 5, 2009
Resumen
En los animales adultos, los recuerdos de miedo están protegidos de la extinción por redes perineuronales (PNN). La degradación de estas redes en adultos hace que los recuerdos de miedo sean borrables, revelando un mecanismo clave para la resiliencia de la memoria.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología Molecular Biología Molecular
- Biología del desarrollo Biología del desarrollo.
Sus antecedentes:
- El condicionamiento del miedo en los adultos crea recuerdos permanentes resistentes a la extinción.
- En contraste, los animales jóvenes pueden borrar los recuerdos de miedo condicionado a través de la extinción.
- Esto sugiere un cambio en el desarrollo en el procesamiento y la protección de la memoria del miedo.
Objetivo del estudio:
- Investigar los mecanismos moleculares subyacentes al cambio de desarrollo en la resiliencia de la memoria del miedo.
- Identificar el papel de los componentes de la matriz extracelular en la protección de los recuerdos de miedo de la extinción en adultos.
Principales métodos:
- Se examinó el papel de los proteoglicanos de sulfato de condroitina (CSPG) y su organización en redes perineuronales (PNN) en la amígdala.
- Investigó el efecto de la degradación de los PNN utilizando la condroitinasa ABC en el borrado de la memoria del miedo en animales adultos.
Principales resultados:
- La organización de CSPGs en PNNs en la amígdala coincidió con el aumento del desarrollo de la resistencia a la memoria del miedo.
- La degradación de los PNN en animales adultos hizo que los recuerdos de miedo recién adquiridos fueran susceptibles de ser borrados por la extinción.
- Se demostró que los PNN intactos son cruciales para la formación de recuerdos de miedo resistentes al borrado.
Conclusiones:
- Los proteoglicanos de sulfato de condroitina de matriz extracelular (CSPG) organizados en redes perineuronales (PNN) en la amígdala confieren resistencia al borrado de la memoria del miedo en animales adultos.
- Las PNN median la formación de recuerdos permanentes de miedo, cerrando efectivamente un período crítico postnatal para el borrado de la memoria.
- Este estudio identifica un mecanismo molecular para la transición del desarrollo de la plasticidad de la memoria del miedo.
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