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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Síntesis asimétrica de ciclopentanonas funcionalizadas a través de una secuencia de cascada catalizada por aminas

Stephen P Lathrop1, Tomislav Rovis

  • 1Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.

Journal of the American Chemical Society
|September 8, 2009
PubMed
Resumen

Este estudio introduce una nueva reacción multicatalítica asimétrica de una sola olla para sintetizar ciclopentanonas funcionalizadas. El proceso eficiente utiliza materiales fácilmente disponibles, logrando una alta enantioselectividad a través de un mecanismo catalítico dual.

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