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El óxido nítrico endógeno protege a las bacterias contra un amplio espectro de antibióticos
Ivan Gusarov1, Konstantin Shatalin, Marina Starodubtseva
1Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Science (New York, N.Y.)
|September 12, 2009
Resumen
Las sintasas bacterianas de óxido nítrico (bNOS) permiten a las bacterias resistir los antibióticos al neutralizar las toxinas y reducir el estrés oxidativo. La inhibición de la bNOS puede mejorar la efectividad de los tratamientos antimicrobianos.
Área de la Ciencia:
- Microbiología Microbiología.
- La bioquímica es la bioquímica.
- La resistencia a los antimicrobianos se ha desarrollado.
Sus antecedentes:
- Las sintasas bacterianas de óxido nítrico (bNOS) se encuentran en bacterias Gram-positivas y producen óxido nítrico (NO) a partir de arginina.
- El significado fisiológico de bNOS en bacterias sigue siendo en gran parte inexplorado.
Objetivo del estudio:
- Para investigar el papel fisiológico de las sintasas de óxido nítrico bacteriano (bNOS).
- Para determinar cómo el NO producido por bNOS afecta la supervivencia bacteriana en presencia de antibióticos.
Principales métodos:
- Investigó la función de bNOS en las bacterias Gram-positivas.
- Evaluó el impacto de la producción de NO en la resistencia bacteriana a varios antibióticos.
- Mecanismos analizados de la resistencia a los antibióticos mediada por NO.
Principales resultados:
- El NO generado por bNOS aumenta significativamente la resistencia bacteriana a una amplia gama de antibióticos.
- La resistencia mediada por NO implica la modificación química de compuestos tóxicos y la mitigación del estrés oxidativo inducido por antibióticos.
- Esta resistencia permite que las bacterias coexistan con los microorganismos productores de antibióticos.
Conclusiones:
- Las sintasas bacterianas de óxido nítrico juegan un papel crucial en la concesión de resistencia a los antibióticos.
- La inhibición de la actividad de bNOS presenta una estrategia potencial para mejorar la eficacia de las terapias antimicrobianas actuales.
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