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Terapia génica para el daltonismo rojo-verde en primates adultos
Katherine Mancuso1, William W Hauswirth, Qiuhong Li
1Department of Ophthalmology, Box 356485, University of Washington, 1959 North East Pacific Street, Seattle, Washington 98195, USA.
Nature
|September 18, 2009
Resumen
La terapia génica restauró con éxito la visión tricromática de los colores en monos adultos daltónicos. Este avance demuestra que el tratamiento de los trastornos congénitos de la visión en adultos es posible, ofreciendo la esperanza de curar la daltonismo.
Área de la Ciencia:
- Oftalmología Oftalmología.
- Genética La genética.
- La neurociencia es la neurociencia.
Sus antecedentes:
- La daltonismo rojo-verde es un trastorno genético común causado por la falta de fotopigmentos L o M.
- Se pensaba que los trastornos de la visión congénita eran intratables en adultos debido a la dependencia de los procesos de desarrollo temprano.
Objetivo del estudio:
- Investigar el potencial de la terapia génica para curar el daltonismo rojo-verde en primates adultos.
- Para determinar si un nuevo pigmento cónico puede restaurar la visión tricromática en la edad adulta.
Principales métodos:
- La terapia génica introdujo una tercera opsina en las retinas de monos adultos daltónicos.
- Las pruebas de comportamiento evaluaron la restauración de la visión tricromática del color.
Principales resultados:
- La adición de un tercer pigmento cono permitió la visión tricromática del color en sujetos adultos.
- La restauración exitosa de la visión del color se produjo sin requerir procesos de desarrollo temprano.
Conclusiones:
- La terapia génica puede establecer la visión tricromática de los colores en primates adultos con daltonismo congénito.
- El tratamiento de los trastornos congénitos de la visión en adultos es factible, desafiando las limitaciones de desarrollo anteriores.
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