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La formación de metástasis independiente de la actividad del VEGFR1
Michelle R Dawson1, Dan G Duda, Dai Fukumura
1Steele Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Nature
|September 18, 2009
Resumen
El bloqueo del receptor 1 del factor de crecimiento endotelial vascular (VEGFR1) no impidió la metástasis en un modelo preclínico. Es probable que las vías alternativas medien la preparación del tejido para la propagación del cáncer.
Área de la Ciencia:
- Oncología Oncología.
- Biología celular Biología celular.
- Biología Molecular Biología Molecular
Sus antecedentes:
- El factor de crecimiento endotelial vascular (VEGF) y el factor de crecimiento placentario (PlGF) regulan la angiogénesis tumoral y están implicados en la movilización de células derivadas de la médula ósea (BMDC).
- Estudios anteriores sugirieron que las BMDC forman "nichos metastásicos" en los pulmones, facilitados por VEGFR1, antes de la llegada de las células cancerosas.
- Se demostró que la inhibición farmacológica de VEGFR1 previene la infiltración de BMDC y la formación de nichos metastásicos en modelos preclínicos.
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