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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Cicloadición formal [4 + 2] de ciclobutanos y aldehídos donantes-aceptantes: acceso estereoselectivo a los

Andrew T Parsons1, Jeffrey S Johnson

  • 1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.

Journal of the American Chemical Society
|September 22, 2009
PubMed
Resumen

Un nuevo método sintetiza eficientemente tetrahidropiranos cis-disubstituidos (THPs) utilizando una cicloadición catalizada por ácido de Lewis. Este enfoque logra altos rendimientos y una excelente diastereoselectividad para varios aldehídos.

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