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Dos componentes de la potenciación a largo plazo inducida por diferentes patrones de activación aferente

L M Grover¹, T J Teyler

¹Neurobiology Department, Northeastern Ohio Universities College of Medicine, Rootstown 44272.

|October 4, 1990

Resumen

Se descubrió una nueva forma de potenciación a largo plazo (LTP) en el hipocampo, independiente de los receptores NMDA. Este mecanismo de memoria se basa en la afluencia postsináptica de calcio y la frecuencia del tétanos.

Área de la Ciencia:

La neurociencia es la neurociencia.
La plasticidad sináptica.
Investigación de la memoria Investigación de la memoria.

Sus antecedentes:

La potenciación a largo plazo (LTP) es un mecanismo clave para la formación de la memoria.
La activación del receptor NMDA generalmente se requiere para la inducción de LTP en el hipocampo y la neocórtex.
El influjo de calcio (Ca2+) en las neuronas postsinápticas es crucial para la LTP.

Objetivo del estudio:

Para investigar un componente de la LTP que no requiere la activación del receptor NMDA.
Explorar vías alternativas para inducir la plasticidad sináptica en el hipocampo.
Comprender el papel de la señalización del calcio en la LTP independiente de NMDA.

Principales métodos:

Registros electrofisiológicos en el área del hipocampo CA1.1.
Inducción de la LTP mediante estimulación de alta frecuencia (tetano).
Manipulación farmacológica utilizando antagonistas de los receptores NMDA y bloqueadores de los canales de calcio dependientes de voltaje.

Principales resultados:

Se indujo con éxito un componente de LTP en el área CA1 sin activar los receptores NMDA.
Esta LTP independiente del NMDA dependía de la frecuencia del tétanos.
La inducción de este componente de la LTP requirió un aumento de las concentraciones postsinápticas de Ca2+ intracelular.
Un antagonista de los canales Ca2+ dependientes de la tensión suprimió esta forma de LTP.

Conclusiones:

Existe una nueva vía para inducir la LTP en el hipocampo, independiente de los receptores NMDA.
Esta vía se basa en el influjo postsináptico de calcio modulado por la frecuencia del tétanos.
Los canales de calcio dependientes de la tensión juegan un papel crítico en esta forma de plasticidad sináptica independiente del NMDA.

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