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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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Las células T reguladoras CD4+ controlan las respuestas TH17 de una manera dependiente de Stat3

Ashutosh Chaudhry1, Dipayan Rudra, Piper Treuting

  • 1Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Science (New York, N.Y.)
|October 3, 2009
PubMed
Resumen

Las células T reguladoras (Tregs) suprimen las respuestas inmunes patógenas del T ayudante 17 (Th17) mediante la regulación de la señalización STAT. La pérdida de Stat3 específico de Treg perjudica esta supresión, lo que lleva a una inflamación fatal.

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