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Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

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Regulación de los reguladores: modificaciones post-traduccionales de los factores de silenciamiento del ARN

Inha Heo¹, V Narry Kim

¹School of Biological Sciences and National Creative Research Initiatives Center, Seoul National University, Seoul 151-742, Korea.

|October 7, 2009

Resumen

Los reguladores del silenciamiento del ARN, incluidos los ARN pequeños y las proteínas asociadas, están sujetos a regulación. Las modificaciones postraslacionales son clave para controlar la función de los factores de silenciamiento del ARN central como Ago, Piwi y TRBP.

Área de la Ciencia:

Biología Molecular Biología Molecular
Regulación genética Reglamento genético.
ARN Biología Biología ARN

Sus antecedentes:

Las vías de silenciamiento del ARN son cruciales para la regulación de la expresión génica.
La especificidad en el silenciamiento del ARN se logra a través de varios mecanismos regulatorios.
Los factores centrales como Argonaute (Ago), Piwi y la proteína de unión al ARN TAR (TRBP) median el silenciamiento del ARN.

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