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Nuevas síntesis de los bloques de construcción E7389 C14-C35 y halichondrina C14-C38: enfoque de doble inversión

Dae-Shik Kim1, Cheng-Guo Dong, Joseph T Kim

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Journal of the American Chemical Society
|October 8, 2009
PubMed
Resumen

Las reacciones de acoplamiento catalítico asimétrico mediado por cromo se utilizaron secuencialmente para sintetizar estereoselectivamente los bloques de construcción de E7389 y la halicondrina. Estos métodos permiten la construcción eficiente de arquitecturas moleculares complejas para potenciales aplicaciones terapéuticas.

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