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Transmisión trans-sináptica de las señales Wnt vesiculares a través de Evi/Wntless
Ceren Korkut1, Bulent Ataman, Preethi Ramachandran
1Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Cell
|October 20, 2009
Resumen
Este estudio revela cómo las proteínas Wnt viajan entre las células utilizando vesículas similares a los exosomas. La proteína de unión a Wnt Evi/Wls/Srt es crucial para la secreción de Wnt y la orientación postsináptica, asegurando la correcta señalización de Wnt.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología celular Biología celular.
- Biología del desarrollo Biología del desarrollo.
Sus antecedentes:
- Las proteínas Wnt son vitales para el desarrollo y la función del sistema nervioso.
- Los mecanismos celulares para el transporte de Wnt entre las neuronas siguen siendo en gran medida desconocidos.
Objetivo del estudio:
- Para aclarar el mecanismo del tráfico de Wnt entre las células.
- Para investigar el papel de la uniformidad interrumpida / Wntless / Sprinter (Evi / Wls / Srt) en la transmisión de Wnt.
Principales métodos:
- Se utilizó el modelo de unión neuromuscular (JNM) larval de Drosophila.
- Se investigó la liberación vesicular presináptica de Evi.
- Se examinó el papel de Evi en la orientación de dGRIP en las células postsinápticas.
Principales resultados:
- La liberación vesicular presináptica de Evi/Wls/Srt es esencial para la secreción sin alas (Wg).
- Evi/Wls/Srt actúa de forma celular autónoma en las células postsinápticas para dirigirse a la proteína dGRIP que interactúa con el receptor Wg.
- La pérdida de la función Evi/Wls/Srt interrumpe la orientación de dGRIP y la transducción de la señal Wnt.
Conclusiones:
- Descubrió un nuevo mecanismo de transporte de Wnt a través de vesículas que contienen Evi/Wls/Srt.
- Evi/Wls/Srt tiene una doble función en la producción y recepción de Wnt.
- Este hallazgo avanza en la comprensión de la señalización Wnt y la función sináptica.
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