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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
Riesgo cardiometabólico de medicamentos antipsicóticos de segunda generación durante el primer uso en niños y
Christoph U Correll1, Peter Manu, Vladimir Olshanskiy
1Zucker Hillside Hospital, Psychiatry Research, North Shore-Long Island Jewish Health System, 75-59 263rd St, Glen Oaks, NY 11004, USA. ccorrell@lij.edu
JAMA
|October 29, 2009
Resumen
Los antipsicóticos de segunda generación causan un aumento significativo de peso en los jóvenes. Los cambios metabólicos varían según el fármaco, con la olanzapina y la quetiapina mostrando los aumentos más preocupantes de lípidos y triglicéridos.
Área de la Ciencia:
- Psiquiatría Pediátrica es una especialidad de la psiquiatría pediátrica.
- Farmacología Farmacología.
- Investigación Metabólica de Investigación.
Sus antecedentes:
- Los riesgos cardiometabólicos de los antipsicóticos de segunda generación (APS) son motivo de preocupación.
- Existe una investigación limitada sobre estos efectos en las poblaciones pediátricas y adolescentes ingenuas con antipsicóticos.
Objetivo del estudio:
- Investigar la asociación entre los AGS y la composición corporal y los parámetros metabólicos.
- Centrarse en pacientes sin exposición previa a los antipsicóticos.
Principales métodos:
- Estudio de cohorte no aleatorizado (SATIETY) de jóvenes de 4 a 19 años.
- El tratamiento con aripiprazol, olanzapina, quetiapina o risperidona durante 12 semanas.
- Resultados comparados con un grupo no tratado.
Principales resultados:
- Los cuatro SGAs llevaron a un aumento de peso significativo en comparación con los controles.
- La olanzapina y la quetiapina mostraron aumentos significativos en el colesterol total, los triglicéridos y el colesterol no HDL.
- La risperidona aumentó los triglicéridos; el aripiprazol no mostró cambios metabólicos significativos.
Conclusiones:
- Iniciar SGAs en la juventud está relacionado con un aumento sustancial de peso.
- Las alteraciones metabólicas difieren entre los AGS estudiados, destacando la necesidad de un monitoreo individualizado.
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