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Updated: Jun 18, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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Published on: January 13, 2017

La base bioquímica para el control estereoquímico en la biosíntesis de policeturo

Chiara R Valenzano1, Rachel J Lawson, Alice Y Chen

  • 1Department of Chemistry, Box H, Brown University, Providence, Rhode Island 02912-9108, USA.

Journal of the American Chemical Society
|November 26, 2009
PubMed
Resumen

Las poliquetidas sintasas controlan la estereoquímica a través de los dominios de las ketorreductasas. La epimerización del grupo metilo se produce después del alargamiento de la cadena, catalizada por el propio dominio de la ketorreductaza.

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