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Induction and Analysis of Epithelial to Mesenchymal Transition
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Las transiciones epitelio-mesenquimales en el desarrollo y en la enfermedad
Jean Paul Thiery1, Hervé Acloque, Ruby Y J Huang
1IMCB, A*STAR, Proteos, Singapore 138673, Republic of Singapore. jpthiery@imcb.a-star.edu.sg
Cell
|December 1, 2009
Resumen
La transición epitelial a mesenquimal (EMT) es vital para el desarrollo y la reparación, pero puede conducir a la fibrosis, la progresión del cáncer y la metástasis promoviendo la migración celular y la estructura del tallo.
Área de la Ciencia:
- Biología celular Biología celular.
- Biología del desarrollo Biología del desarrollo.
- Biología del cáncer Biología del cáncer.
Sus antecedentes:
- La transición epitelial a mesenquimal (TME) es un proceso biológico fundamental.
- La EMT es crítica para el desarrollo embrionario y la reparación de tejidos.
- La EMT desregulada está implicada en enfermedades como la fibrosis y el cáncer.
Objetivo del estudio:
- Aclarar las múltiples funciones de los EMT en los procesos biológicos.
- Comprender cómo la EMT contribuye tanto al desarrollo normal como a las condiciones patológicas.
- Para resaltar los mecanismos celulares que subyacen a las funciones de EMT.
Principales métodos:
- Este estudio es una revisión de la literatura existente sobre EMT.
- Análisis de los mecanismos moleculares que impulsan el EMT.
- Examen de las consecuencias de la EMT en el desarrollo y la enfermedad.
Principales resultados:
- La EMT facilita la migración celular, la invasión, la estructura del tallo y la resistencia a la apoptosis y la senescencia.
- El estado mesenquimal inducido por la EMT es crucial para el desarrollo y la metástasis.
- La EMT contribuye a la inmunosupresión, ayudando a la progresión del tumor.
Conclusiones:
- EMT es un poderoso programa celular con doble función en la salud y la enfermedad.
- Comprender los mecanismos de la EMT es clave para desarrollar terapias para el cáncer y la fibrosis.
- El papel de la EMT en el estímulo y la migración es fundamental para sus funciones de desarrollo y metastásicas.
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