Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Lines01:16

Cell Lines

A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Ultrasound phacoemulsification: Physical mechanisms, cavitation, and thermal effects.

Journal of cataract and refractive surgery·2026
Same author

Investigation of laser damage resistance of a sapphire-substrate-based resonant waveguide grating exposed to sub-picosecond pulses.

Optics express·2026
Same author

Pulse compressor grating-waveguide structure for high-power chirped pulse amplification at wavelengths around 2 µm.

Optics express·2026
Same author

Effect of free thermohaline convection on radionuclide transport in fractured-porous media near salt domes.

Journal of contaminant hydrology·2026
Same author

Leaky Sewers Hydraulically Disconnect from Groundwater: A Proof-of-Concept.

Ground water·2026
Same author

Regulation of lineage reprogramming by dynamic chromatin SUMOylation.

Cellular and molecular life sciences : CMLS·2026
Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026
Same journal

China boosts prestigious grants for young scientists - will it ease competition?

Nature·2026
Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026
Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026
Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026
Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jun 18, 2026

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
07:48

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

Published on: December 18, 2015

Forzando a las células a cambiar de linaje.

Thomas Graf1, Tariq Enver

  • 1Center for Genomic Regulation and ICREA, 08003 Barcelona, Spain. thomas.graf@crg.es

Nature
|December 4, 2009
PubMed
Resumen
Este resumen es generado por máquina.

La pluripotencia inducida (reprogramación iPS) revive el interés en la reprogramación directa del linaje celular. Esta técnica ofrece un método poderoso para estudiar el destino celular y tiene potencial para aplicaciones terapéuticas.

Más Videos Relacionados

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors
11:46

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

Published on: December 14, 2018

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
07:53

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

Published on: January 1, 2018

Videos de Experimentos Relacionados

Last Updated: Jun 18, 2026

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
07:48

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

Published on: December 18, 2015

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors
11:46

Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

Published on: December 14, 2018

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
07:53

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

Published on: January 1, 2018

Área de la Ciencia:

  • Biología celular Biología celular.
  • Biología del desarrollo Biología del desarrollo.
  • Biología molecular La biología molecular.

Sus antecedentes:

  • La pluripotencia inducida (reprogramación iPS) permite la generación de células madre.
  • Se ha demostrado que los factores de transcripción convierten directamente células especializadas entre linajes.

Objetivo del estudio:

  • Para explorar las implicaciones de la reprogramación de linaje directo.
  • Para resaltar su utilidad en la comprensión de la determinación del destino celular.
  • Para discutir su potencial para estrategias terapéuticas.

Principales métodos:

  • Revisión de estudios anteriores sobre la conversión celular mediada por el factor de transcripción.
  • Análisis de las técnicas de pluripotencia inducida (reprogramación de iPS).
  • Exploración de los mecanismos de elección del destino celular durante la diferenciación.

Principales resultados:

  • La reprogramación de linaje directo es un método viable para los estudios del destino celular.
  • Este enfoque proporciona conocimientos comparables a los estudios de mutación genética.
  • La comprensión obtenida puede informar la manipulación celular terapéutica.

Conclusiones:

  • La reprogramación del linaje es una herramienta valiosa para la investigación biológica.
  • Ofrece un marco para el desarrollo de nuevas intervenciones terapéuticas.
  • Una mayor investigación sobre la manipulación celular es muy prometedora.