Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

L1CAM signaling through planar cell polarity drives SOX2 expression and lung adenocarcinoma metastasis.

Nature communications·2026
Same author

NSCLC brain metastases exhibit reduced HLA-I antigen presentation machinery and immune evasion independent of IFNγ signaling defects.

Molecular cancer·2026
Same author

Metastasis as a Multiorgan Disease: Toward Organ-Informed Precision Oncology.

Cancer discovery·2026
Same author

CLO26-115: Association Between Geriatric Assessment Variables and Treatment Completion in Older Adults With Triple-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy and Immunotherapy: The MSKCC Experience.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Homologous recombination deficiency and hemizygosity drive resistance in breast cancer.

Nature·2026
Same author

Tumor Cell Clustering Enhances Metastatic Competence by Regulating the H3K36 Histone Demethylase KDM2A.

bioRxiv : the preprint server for biology·2026

Video Experimental Relacionado

Updated: Jun 17, 2026

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion
05:23

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

La auto-siembra del tumor por las células cancerosas circulantes.

Mi-Young Kim1, Thordur Oskarsson, Swarnali Acharyya

  • 1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Cell
|January 13, 2010
PubMed
Resumen

Las células cancerosas pueden volver a su tumor original, un proceso llamado auto-siembra tumoral. Este comportamiento agresivo de las células tumorales circulantes (CTC) acelera el crecimiento del cáncer y puede explicar la recurrencia local después de la cirugía.

Más Videos Relacionados

Lung Tumor Cell Recruitment Assay
04:28

Lung Tumor Cell Recruitment Assay

Published on: February 26, 2019

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

Videos de Experimentos Relacionados

Last Updated: Jun 17, 2026

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion
05:23

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

Lung Tumor Cell Recruitment Assay
04:28

Lung Tumor Cell Recruitment Assay

Published on: February 26, 2019

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
06:09

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections

Published on: February 9, 2020

Área de la Ciencia:

  • Oncología Oncología.
  • Biología del cáncer Biología del cáncer.
  • Investigación de la Metástasis Investigación de las Metástasis

Sus antecedentes:

  • La metástasis se considera tradicionalmente como una propagación unidireccional de las células cancerosas desde un tumor primario a sitios distantes.
  • El destino y el comportamiento de las células tumorales circulantes (CTC) después de la diseminación no se comprenden completamente.

Objetivo del estudio:

  • Investigar el potencial de las células tumorales circulantes (CTC) para colonizar sus tumores de origen.
  • Identificar los mecanismos y consecuencias de este proceso de "auto-siembra tumoral" en modelos preclínicos de cáncer.

Principales métodos:

  • Utilizó modelos de ratón de cáncer de mama, cáncer de colon y melanoma.
  • Se analizó el papel de citoquinas específicas (IL-6, IL-8), enzimas (MMP1/colagenasa-1) y componentes del citoesqueleto (fascin-1) en la infiltración del CTC.
  • Investigó el impacto de la auto-siembra en el crecimiento tumoral, la angiogénesis y el reclutamiento de células estomales, examinando factores como CXCL1.

Principales resultados:

  • Se demostró que los CTCs agresivos, incluidos aquellos con tropismo metastásico para hueso, pulmón o cerebro, pueden colonizar sus tumores primarios (auto-siembra tumoral).
  • Identificó IL-6 e IL-8 como atractores clave para las CTC y MMP1/colagenasa-1 y fascin-1 como mediadores de la infiltración en los tumores mamarios.
  • Se demostró que la auto-siembra acelera el crecimiento tumoral, la angiogénesis y el reclutamiento estromal, en parte a través de CXCL1.

Conclusiones:

  • Las células tumorales circulantes (CTC) pueden colonizar sus tumores de origen, desafiando el modelo de metástasis unidireccional.
  • La auto-siembra del tumor, mediada por CTCs agresivos y factores moleculares específicos, puede mejorar la progresión del tumor.
  • Este proceso puede dilucidar los vínculos entre las características del tumor, el pronóstico y la recurrencia local después de una resección aparentemente completa.