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The Preparation of Electrohydrodynamic Bridges from Polar Dielectric Liquids
Published on: September 30, 2014
Las moléculas dipolares como impulsores logran la liberación estimulada por el campo eléctrico
Yingchun Zhu1, Huijuan Liu, Fang Li
1Key Lab of Inorganic Coating Materials, Shanghai Institute of Ceramics, CASS, Shanghai 200050, China. yzhu@mail.sic.ac.cn
Journal of the American Chemical Society
|January 19, 2010
Resumen
Los investigadores desarrollaron un nuevo sistema de liberación controlada por campo eléctrico utilizando moléculas dipolares como nanoimpulsores. Este sistema permite la administración de fármacos dirigida y remota para aplicaciones potenciales en el tratamiento de tumores.
Área de la Ciencia:
- Nanotecnología La nanotecnología es la nanotecnología.
- Ciencia de los materiales Ciencia de los materiales.
- Ingeniería Biomédica Ingeniería Biomédica.
Sus antecedentes:
- Los sistemas de liberación controlada son cruciales para la administración dirigida de fármacos.
- Los métodos existentes a menudo carecen de un control externo preciso o pueden ser invasivos.
Objetivo del estudio:
- Diseñar y demostrar un nuevo sistema de liberación controlada por campo eléctrico externo.
- Para utilizar moléculas dipolares funcionales como nanoimpulsores para una manipulación molecular precisa.
Principales métodos:
- Sintetizó la molécula dipolar 4-(3-cianofenil)butileno con un fuerte momento dipolar.
- Injerto de la molécula en las superficies internas de los materiales mesoporosos.
- Se aplicaron campos eléctricos alternos para inducir la reorientación molecular y la posterior liberación.
Principales resultados:
- Las moléculas dipolares se reorientaron con éxito en respuesta a los campos eléctricos externos.
- Los campos eléctricos alternos indujeron a los "nanoimpellers" a empujar las moléculas huéspedes fuera de los mesoporos.
- Liberación efectiva y controlada externamente demostrada de sustancias encapsuladas.
Conclusiones:
- El sistema desarrollado ofrece un nuevo paradigma para la liberación controlada por campo eléctrico externo.
- Esta tecnología es prometedora para el tratamiento dirigido de tumores debido a su control remoto y capacidades de liberación local.
- La naturaleza no electroquímica del proceso ofrece una ventaja sobre otros métodos.
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