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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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Síntesis enantioselectiva de indanonas sustituidas de los sililoxialenos

Jonathan A Brekan1, Troy E Reynolds, Karl A Scheidt

  • 1Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Northwestern University, Silverman Hall, Evanston, Illinois 60208, USA.

Journal of the American Chemical Society
|January 21, 2010
PubMed
Resumen

Una nueva síntesis asimétrica crea endanonas enriquecidas con enantio a partir de precursores racémicos. Este método transfiere eficientemente la quiralidad, produciendo indanonas e indenas altamente sustituidas con un excelente control estereoquímico.

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