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A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
Published on: February 19, 2019
Esencialidad de la vía FASII para el Staphylococcus aureus
Wendy Balemans1, Nacer Lounis, Ron Gilissen
1Department of Antimicrobial Research, Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Nature
|January 22, 2010
Resumen
La biosíntesis de ácidos grasos tipo II (FASII) es un objetivo antibacteriano viable para Staphylococcus aureus, contrariamente a las sugerencias recientes. Nuestros hallazgos desafían la noción de que los patógenos Gram-positivos no pueden ser atacados a través de la inhibición de FASII.
Área de la Ciencia:
- Microbiología Microbiología.
- La bioquímica es la bioquímica.
- Descubrimiento de Drogas Descubrimiento de Drogas
Sus antecedentes:
- Estudios recientes sugirieron que los patógenos Gram-positivos, incluido Staphylococcus aureus, no son objetivos adecuados para los medicamentos antibacterianos que inhiben la biosíntesis de ácidos grasos tipo II (FASII). Esto se basó en la premisa de que estas bacterias utilizan ácidos grasos derivados del huésped en lugar de sintetizar los suyos propios.
- Esta hipótesis, si es precisa, tendría un impacto significativo en los esfuerzos de investigación y desarrollo de nuevos antibióticos dirigidos a la vía FASII, lo que podría redirigir las inversiones lejos de esta prometedora área.
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