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Las células y la representación periférica del sabor al sodio en ratones
Jayaram Chandrashekar1, Christina Kuhn, Yuki Oka
1Howard Hughes Medical Institute and Department of Neurobiology, University of California at San Diego, La Jolla, California 92093-0649, USA
Nature
|January 29, 2010
Resumen
Los ratones que carecen del canal de sodio epitelial (ENaC) en las células del gusto pierden la atracción por la sal. Este estudio confirma el ENaC.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología Sensorial Biología Sensorial
- Percepción del gusto de los mamíferos Percepción del gusto de los mamíferos
Sus antecedentes:
- El sabor salado de los mamíferos provoca atracción o aversión en función de la concentración.
- La atractiva vía de la sal es específica para el sodio y sensible a la amilorida.
- El canal de sodio epitelial (ENaC) está implicado en la detección del sabor de la sal.
Objetivo del estudio:
- Para investigar el papel de ENaC en las células receptoras del gusto dedicadas (TRC) para la detección de sodio.
- Para determinar si ENaC media la atracción conductual hacia la sal.
Principales métodos:
- Ingeniería genética de ratones que carecen de ENaCalpha específicamente en TRCs.
- Análisis conductual de la atracción por la sal y las respuestas al sabor del sodio en ratones modificados genéticamente.
- Comparación con los mecanismos establecidos para otras modalidades básicas de sabor.
Principales resultados:
- Se identificaron TRCs dedicados que expresan ENaC como responsables de la detección de sodio.
- Los ratones que carecían de ENaCalpha en los TRC mostraron una pérdida completa de la atracción por la sal.
- Estos ratones también exhibieron respuestas de sabor de sodio abolido.
Conclusiones:
- ENaC es esencial para mediar la atracción conductual hacia el sodio.
- Esto valida un sustrato celular dedicado para la percepción del sabor del sodio.
- Las cinco cualidades básicas del sabor ahora están sustentadas por mecanismos celulares independientes.
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