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Videos de Conceptos Relacionados

Microtubules in Cell Motility01:24

Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Introduction to the Cytoskeleton01:33

Introduction to the Cytoskeleton

Overview of the Cytoskeleton
The cytoskeleton is a network of protein filaments present within the cell, having three distinct filaments ̶   microfilaments, microtubules, and intermediate filaments. Each has characteristic features that distinguish them, including the dynamics of their assembly and disassembly, mechanical properties, polarity, and the type of molecular motors associated with them. Earlier, they were thought to be present only in eukaryotic cells; however, their homologs were...
The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
Polarity of the Cytoskeleton01:18

Polarity of the Cytoskeleton

The intrinsic polarity of cells can be primarily attributed to two factors- i) the asymmetric accumulation of mobile components such are regulatory molecules and subcellular components across the cell and ii) the orientation of polar cytoskeletal filaments that make up the cytoskeletal networks, specifically microfilaments, and microtubules arranged along the axis of polarity. Interactions between the cytoskeletal filaments are crucial for the establishment and maintenance of the polar nature...

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Video Experimental Relacionado

Updated: Jun 16, 2026

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics
09:10

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics

Published on: August 25, 2022

La mecánica celular y el citoesqueleto.

Daniel A Fletcher1, R Dyche Mullins

  • 1Bioengineering and Biophysics, University of California, Berkeley, California 94720, USA. fletch@berkeley.edu

Nature
|January 30, 2010
PubMed
Resumen

La célula La célula es la célula.

Área de la Ciencia:

  • Biología celular Biología celular.
  • La biofísica es la biofísica.

Sus antecedentes:

  • El citoesqueleto, una red de polímeros y proteínas, gobierna la mecánica celular, el transporte y la forma.
  • Las fuerzas físicas influyen en las propiedades citoesqueléticas y el comportamiento celular.
  • Comprender la transmisión de la fuerza en el citoesqueleto es crucial.

Objetivo del estudio:

  • Investigar cómo las redes citoesqueléticas generan, transmiten y responden a señales mecánicas.
  • Explorar el papel de las estructuras citoesqueléticas de larga vida en el destino celular.

Principales métodos:

  • Análisis de la dinámica del citoesqueleto.
  • Aplicación y medición de la fuerza mecánica.
  • Análisis epigenético de las estructuras citoesqueléticas.

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The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton
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The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

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Videos de Experimentos Relacionados

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Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics
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Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics

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The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton
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The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

Published on: March 10, 2023

Principales resultados:

  • Las redes citoesqueléticas gestionan activamente las señales mecánicas a través de escalas de tiempo.
  • Las estructuras citoesqueléticas de larga vida exhiben propiedades epigenéticas.
  • Las fuerzas mecánicas afectan las propiedades y el comportamiento de las células locales.

Conclusiones:

  • La señalización mecánica del citoesqueleto es clave para las funciones celulares.
  • Las arquitecturas citoesqueléticas estables pueden actuar como determinantes epigenéticos.
  • Esta investigación proporciona información sobre la mecánica celular y la regulación epigenética.